IOVANCE BIOTHERAP.DL-,001 WKN: A2DT49 ISIN: US4622601007 Kürzel: IOVA Forum: Aktien Thema: Hauptdiskussion

https://www.fiercepharma.com/pharma/asco-bristol-myers-i-o-triplet-iovance-touts-paradigm-changing-amtagvi-keytruda-melanoma

23.05.2024: Data in Published Abstract and Upcoming Oral Presentation Strongly Support Ongoing TILVANCE-301 Phase 3 Trial SAN CARLOS, Calif., May 23, 2024 (GLOBE NEWSWIRE) -- Iovance Biotherapeutics, Inc. (NASDAQ: IOVA), a commercial biotechnology company focused on innovating, developing, and delivering novel polyclonal tumor infiltrating lymphocyte (TIL) therapies for patients with cancer, today announced updated clinical data for lifileucel in combination with pembrolizumab in frontline advanced melanoma, as well as translational data, for the upcoming 2024 ASCO Annual Meeting to be held May 31 – June 4, 2024, at McCormick Place in Chicago, IL and online. Clinical Data in Frontline Advanced Melanoma (Cohort 1A in IOV-COM-202 Trial) Positive results from Cohort 1A in the IOV-COM-202 trial were published in an abstract1 and will be highlighted in an upcoming oral presentation at ASCO. Unprecedented response rates, as well as deep and durable responses, were observed in patients with frontline advanced melanoma who were naïve to immune checkpoint inhibitor (ICI) therapy. These results strongly support the ongoing Phase 3 TILVANCE-301 clinical trial. ASCO Oral Presentation Highlights A recent data cut included 23 patients with a median follow up of 21.7 months.2 Confirmed ORR was 65.2%, including 7 (30.4%) complete responses and 8 (34.8%) partial responses by RECIST v1.1. All evaluable patients demonstrated regression of their target lesions. Nearly all responses remained ongoing. The duration of response was 12+ months for 8 responders (53.3%) and 6+ months for 11 responders (73.3%). As a one-time treatment, lifileucel’s safety profile was differentiated from continuous ICI combination regimens. Treatment-emergent adverse events were consistent with the underlying disease and known safety profiles of pembrolizumab monotherapy, nonmyeloablative lymphodepletion, and interleukin-2. Friedrich Graf Finckenstein, M.D., Chief Medical Officer of Iovance, stated, “The compelling response rates, including a 30.4% complete response rate, and depth and durability of responses for lifileucel in combination with pembrolizumab strongly support our strategy in frontline advanced melanoma. Expanding TIL cell therapy into earlier treatment settings is a top priority for Iovance. The positive data are highly encouraging for the anticipated ORR results in our ongoing TILVANCE-301 trial. A planned early interim analysis of ORR, a dual primary endpoint in TILVANCE-301, may support an accelerated approval in the frontline setting, with full approval supported by progression free survival.”

Schau doch mal bei Canopy Growth vorbei. Die haben bestimmt noch ein paar Raketen für Dich übrig. 😂

Aber ohne Raketengespamme weiß ich doch gar nicht das ich aussteigen muss.🤣

https://www.fiercepharma.com/pharma/asco-bristol-myers-i-o-triplet-iovance-touts-paradigm-changing-amtagvi-keytruda-melanoma

Wahre worte

Silence is golden.😉 Ist mir lieber, als das Rumgeheule und Bashing in anderen Foren. Wir flippen hier halt nicht direkt bei jeder News aus Wenn der, von mir erwartete Buyout kommt, dann vielleicht schon eher.😉 Einfach mal die Tage, insbesondere die ASCO, abwarten.

Geduld ist alles,wichtig ist man weiß was man hält und sich auch selber schlau macht. 👌, bin auch noch rot und habe meinen Einkaufspreis immer weiter gesenkt.Heute wird nicht viel passieren und wenn nicht so wie wir es uns wünschen würden. Langes Wochenende in den USA und der Markt ist zu unruhig zur Zeit.

Bin mal mit ner kleinen Posi rein

Ist noch nicht mal premarket. Abwarten

Aber ein bisschen getan hat sich jetzt trotzdem was, oder?

Ja die lieben kursziele. Ocuphire, matinas biopharma, protalix...alles tolle kursziele nur den Kurs juckt es nicht:-)

Guten Morgen, Kursziel immer noch 34$

Guten morgen. Trotz positiver Daten tote Hose hier?

https://www.defenseworld.net/2024/05/22/iovance-biotherapeutics-inc-nasdaqiova-receives-consensus-rating-of-buy-from-analysts.html

Wenn die Optionen bei 20$ ausübbar wären würde ich dir ja Recht geben aber so ist es ein nonevent.