Annovis Bio WKN: A2PNH2 ISIN: US03615A1088 Kürzel: ANVS Forum: Aktien User: Schorsch11

Sehe ich etwas anders. Das sind P3 Ergebnisse, die enorm wichtig für eine spätere Zulassung sind. Entscheidend ist hier die Meinung der FDA.

Komisch?

Nein. Vorbörse darf man seltenst ernst nehmen. Nur wenn ein heftiger Kauf oder Verkaufsdruck dahinter steckt. Aktuell steht der Kurs bei 8,66 US Dollar. 32 Aktien haben diesen Sprung von 13,20% verursacht.

Drunter

Enttäuschung :/

Starten aber bei 7,66 Dollar

Im Grunde, ist das alles nur für diejenigen interessant, die noch vor den PD Daten aussteigen wollen. Ist hier jemand, der plant vorher auszusteigen ?

AH 8,15$ sieht doch ok aus

Noch sind wir drüber??.

$ANVS: Annovis Announces New Publication in a Peer-Reviewed Journal MALVERN, Pa., May 21, 2024 (GLOBE NEWSWIRE) -- Annovis Bio, Inc. (NYSE: ANVS) (“Annovis” or the “Company”), a clinical-stage drug platform company developing novel therapies for neurodegenerative diseases, announced the publication of a new article focused on the comparison of pharmacokinetic profiles of Posiphen (or buntanetap) across different species in a peer-reviewed journal *Biomolecules* as part of the Special Issue: Role of Amyloid Protein in Neurological Diseases. “This publication is a testament to many years of research at Annovis. While we have conducted numerous studies to advance our Posiphen pipeline, this is the first systematic and comprehensive comparison in multiple animal and human samples," says Maria Maccecchini, Ph.D., Founder, President, and CEO of Annovis. "Consolidating all this data into one publication offers a more holistic view of Posiphen, enhancing our understanding of its mechanisms.” **Title**: Comparative Analysis of Posiphen Pharmacokinetics across Different Species—Similar Absorption and Metabolism in Mouse, Rat, Dog and Human **Summary:** This article synthesizes findings from various preclinical and clinical studies on Posiphen's absorption and metabolism from mice, rats, dogs, and humans. The aim was to better understand the differences in the drug’s pharmacokinetic behavior, identify which animal models most closely mimic human responses, and explore the potential clinical implications of these variations. **Key highlights:** * Posiphen quickly reaches peak concentration in plasma, followed by high absorption in the brain and cerebrospinal fluid (CSF). * Posiphen metabolizes into two primary metabolites: N1-norposiphen and N8-norposiphen. * Both Posiphen and its metabolites exhibit rapid clearance in animal models and human subjects; however, in the CSF or the brain, the drug stays longer. * Posiphen's absorption, distribution, metabolism, and excretion are similar in healthy volunteers and patients with Alzheimer’s and Parkinson’s diseases. The article can be found on the journal’s website via the link. ARTICLE: [https://www.mdpi.com/2218-273X/14/5/582](https://www.mdpi.com/2218-273X/14/5/582) FULL RELEASE: [https://irpages2.eqs.com/websites/annovis/English/431010/us-press-release.html?airportNewsID=98e152c8-60ff-4d1c-9f55-8dbc9fbfa988](https://irpages2.eqs.com/websites/annovis/English/431010/us-press-release.html?airportNewsID=98e152c8-60ff-4d1c-9f55-8dbc9fbfa988)

Augenmerk 7,39/7,51$ …sonst M-Formation und es geht noch deutlich weiter runter

Das ist ja das spannende an den Ami-Aktien schnell hoch oder rasant abwärts ...schöner als Roulette.....😎

D.h. jetzt geht es wieder aufwärts?

Genau am Fibonacci 0,5 abgeprallt….