Annovis Bio WKN: A2PNH2 ISIN: US03615A1088 Kürzel: ANVS Forum: Aktien User: Schorsch11

$ANVS: Annovis Announces New Publication in a Peer-Reviewed Journal MALVERN, Pa., May 21, 2024 (GLOBE NEWSWIRE) -- Annovis Bio, Inc. (NYSE: ANVS) (“Annovis” or the “Company”), a clinical-stage drug platform company developing novel therapies for neurodegenerative diseases, announced the publication of a new article focused on the comparison of pharmacokinetic profiles of Posiphen (or buntanetap) across different species in a peer-reviewed journal *Biomolecules* as part of the Special Issue: Role of Amyloid Protein in Neurological Diseases. “This publication is a testament to many years of research at Annovis. While we have conducted numerous studies to advance our Posiphen pipeline, this is the first systematic and comprehensive comparison in multiple animal and human samples," says Maria Maccecchini, Ph.D., Founder, President, and CEO of Annovis. "Consolidating all this data into one publication offers a more holistic view of Posiphen, enhancing our understanding of its mechanisms.” **Title**: Comparative Analysis of Posiphen Pharmacokinetics across Different Species—Similar Absorption and Metabolism in Mouse, Rat, Dog and Human **Summary:** This article synthesizes findings from various preclinical and clinical studies on Posiphen's absorption and metabolism from mice, rats, dogs, and humans. The aim was to better understand the differences in the drug’s pharmacokinetic behavior, identify which animal models most closely mimic human responses, and explore the potential clinical implications of these variations. **Key highlights:** * Posiphen quickly reaches peak concentration in plasma, followed by high absorption in the brain and cerebrospinal fluid (CSF). * Posiphen metabolizes into two primary metabolites: N1-norposiphen and N8-norposiphen. * Both Posiphen and its metabolites exhibit rapid clearance in animal models and human subjects; however, in the CSF or the brain, the drug stays longer. * Posiphen's absorption, distribution, metabolism, and excretion are similar in healthy volunteers and patients with Alzheimer’s and Parkinson’s diseases. The article can be found on the journal’s website via the link. ARTICLE: [https://www.mdpi.com/2218-273X/14/5/582](https://www.mdpi.com/2218-273X/14/5/582) FULL RELEASE: [https://irpages2.eqs.com/websites/annovis/English/431010/us-press-release.html?airportNewsID=98e152c8-60ff-4d1c-9f55-8dbc9fbfa988](https://irpages2.eqs.com/websites/annovis/English/431010/us-press-release.html?airportNewsID=98e152c8-60ff-4d1c-9f55-8dbc9fbfa988)

Noch sind wir drüber??.

AH 8,15$ sieht doch ok aus

Im Grunde, ist das alles nur für diejenigen interessant, die noch vor den PD Daten aussteigen wollen. Ist hier jemand, der plant vorher auszusteigen ?

Das ist ja das spannende an den Ami-Aktien schnell hoch oder rasant abwärts ...schöner als Roulette.....😎

D.h. jetzt geht es wieder aufwärts?

Genau am Fibonacci 0,5 abgeprallt….

Oh Mann, unberechenbar das Teil.

Das frage ich mich auch

Wie weit geht's runter?

Aufwärtstrend verlassen…wieder Test am 0,5 Fibonacci

Ich auch nicht. Könnte jetzt wieder grenzwertig werden?

Keine Ahnung, bin bei Charttechnik eher Laie und weiß nur das nötigste

Ist hier der Aufwärtstrend noch intakt oder war es das erstmal?